Reading room
Experiments with different beginnings
Developmental exposure is the entrance. The other papers change the starting age, the material, the preparation or the period of observation.
Lifespans and starting ages
The fruit-fly developmental-exposure paper is the natural beginning for this collection. Beside it sit the female Swiss-derived SHR mouse study and the elderly human Epithalamin follow-up. I would read their descriptions of the intervention before comparing their outcomes.
Culture experiments
The mouse post-ovulatory oocyte experiment works over hours. The telomerase-negative fibroblast experiment begins with a stated cellular condition, while the later cell-line study uses different exposure periods for normal and cancer cells. The review of proposed mechanisms provides a wider context and calls attention to limited characterisation.
- Effect of epitalon on the lifespan increase in Drosophila melanogaster ↗
- Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice ↗
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro ↗
- Peptides of pineal gland and thymus prolong human life ↗
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties ↗
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells ↗
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity ↗